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Proteins that are involved in breaking down muscle are downregulated, meaning less of them are made. Some researchers theorize it is because in the body they become too "weak". "What we found is that in the context of a diet where you are consuming very low levels of nutrients, there was no change in muscle protein synthesis in response to resistance exercise," Nieuwenhuys says. "The changes in muscle protein synthesis were more in the presence of the exercise, so the idea behind it is that when you get into the range of protein intake, the proteins you're taking in are getting replaced by the ones you're removing from your muscle. That means a significant portion of the protein you're consuming in response to your training actually goes into the non-essential amino acids in the same way you replace muscle protein after a period or two off." "The study really underscores the fact that when you're training and your metabolism is going up, so is your muscle protein synthesis," says co-author Jennifer Muth. "So it really does seem that you end up consuming less of the protein you're getting." This is not the first time the study of resistance exercise has led to the idea that resistance training alters the body's ability to synthesize protein. In 2009, a small trial of 40 men, published in the journal Medicine & Science in Sports & Exercise reported that when their bodies were given extra time between training sessions to digest and digest protein, muscle proteins increased significantly after exercise. "With these studies, they're really trying to show the direct impact that training has on the body's ability to synthesize protein. The idea being we're getting into a high-end or extreme exercise environment, then we're increasing the metabolic demand that you have, and you can begin to increase muscle protein synthesis but this comes along with a higher metabolic demand," Muth says. The reason why is that muscles are in constant communication, exchanging information about how much energy and nutrients they need to maintain, repair and increase muscle size. "So when a muscle works hard, it really helps to keep it stimulated," Nieuwenhuys says. "So your body has a way of telling your muscle that 'Hey, we're kind of tired and you've got a bunch of resources to devote to this, so let's let it rest for as long as possible.' So your muscle can go into 'overreaction', or 'off-loading' to accommodate your training. So you do a lot more exercise and you use up a lot of things on your body." Related Article: